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Melatonin supplements can interact with some types of medicine, including: Other, less common melatonin side effects might include:īecause melatonin can cause drowsiness, don't drive or use machinery within five hours of taking it. The most common melatonin side effects include: Unlike with many sleep medications, with melatonin you are unlikely to become dependent on it, have less response to it after repeated use or experience a hangover effect. Melatonin is generally safe for short-term use.
